Untargeted metabolomics approach to discriminate mistletoe commercial products

نویسندگان

چکیده

Abstract Mistletoe ( Viscum album L.) is used in German-speaking European countries the field of integrative oncology linking conventional and complementary medicine therapies to improve quality life. Various companies sell extracts, fermented or not, for injection by subcutaneous intra-tumoral route with a regulatory status anthroposophic medicinal products (European Medicinal Agency (EMA) assessment status). These as well anthroposophical physicians argue that complex matrices composed many molecules mixture are necessary activity host tree mistletoe parasitic plant main determining factor this matrix composition. The critical point parenteral devices extracts do not have standard chemical composition regulated EMA guidelines, because they drugs, speaking. However, mechanism mistletoe’s anticancer its effectiveness treating supporting cancer patients fully understood. Because lack transparency knowledge regarding composition, we undertook an untargeted metabolomics study several explore compare their fingerprints LC-(HR)MS(/MS) 1 H-NMR. Unexpectedly, showed was primarily driven manufacturer/preparation method rather than different trees. This differential may cause differences immunostimulating anti-cancer activities commercially available illustrated structure–activity relationships based on LC–MS/MS H-NMR identifications completed docking experiments. In conclusion, order move towards evidence-based use mistletoe, it priority bring rigor quality, chemically

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2021

ISSN: ['2045-2322']

DOI: https://doi.org/10.1038/s41598-021-93255-z